TREG Lyme Arthritis

  1. Nardelli D, Burchill M, England D, Torrealba J, Callister S, Schell R. Association of CD4+ CD25+ T cells with prevention of severe destructive arthritis in Borrelia burgdorferi-vaccinated and challenged gamma interferon-deficient mice treated with anti-interleukin-17 antibody. Clin Diagn Lab Immunol 2004; 6: 1075-84.
  2. Nardelli D, Cloute J, Luk K, Torrealba J, Warner T, Callister S, Schell R. CD4(+) CD25(+) T cells prevent arthritis associated with Borrelia vaccination and infection. Clin Diagn Lab Immunol 2005; 6: 786-92.
  3. Kisand K, Prukk T, Kalbe I, Uibo R. Propensity to excessive pro-inflammatory response in chronic Lyme borrliosis. APMIS 2007; 2: 134-41.
  4. de Kleer I, Wedderburn L, Taams L, Patel A, Varsani H, Klein M, de Jager W, Pugayung G, Giannoni F, Riikers G, Albani S, Kuis W, Prakken B. CD4+CD25bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis. J Immunol 2004; 10: 6435-43.
  5. Raghavan S, Cao D, Widhe M, Roth K, Herrath J, Engstrom M, Roncador G, Banham A, Trollmo C, Catrina A, Malmstron V. Ann Rheum Dis 2009; 12: 1908-15.  FOXP3 expression in blood, synovial fluid and synovial tissue during inflammatory arthritis and intra-articular corticosteroid treatment.
  6. Shin J, Glickstein L, Steere A. High levels of inflammatory chemokines and cytokines in joint fluid and synovial tissue throughout the course of antibiotic-refractory Lyme arthritis. Arthritis Rheum 2007; 4: 1325-35.
  7. Shen S, Shin J, McHugh G, Li X, Glickstein L, Drouin E, Steere A. Treg cell numbers and function in patients with antibiotic-refractory or antibiotic-responsive Lyme arthritis. Arthritis Rheum 2010; 7: 2127-37.
  8. Vudattu N, Strie K, Steere A, Drouin E. Dysregulation of CD4+CD25(high) T cells in the synovial fluid of patients with antibiotic-refractory Lyme arthritis. Arthritis Rheum 2013; 6: 1643-53.
  9. Amedei A, Codola G, Ozolins D, Ballerini C, Biagioli T, Jaunalksne I, Zilevica A, D Elios S, De Bernard M, D’Elios M. Cerebrospinal fluid T-regulatory cells recognize Borrelia burgdorferi NAPA in chronic Lyme borreliosis. Int J Immunopathol Pharmacol 2013; 4: 907-15.
  10. Grygorczuk S, Chmielewski T, Zajkowska J, Swierzbinska R, Pancewicz S, Kondrusik M, Tylewska-Wierzbanowska S, Hermanowska-Szpakowicz T. Adv Med Sci 2007; 52: 174-8.  Concentration of TGF beta-1 in the supernatant of peripheral blood mononuclear cell cultures from patients with early disseminated and chronic Lyme borreliosis.

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