Lyme_HLA_Genetic Susceptibility


  1. Benoit V, Petrich A, Alugupalli K, Marty-Roix R, Moter A, Leong J, Boyartchuk V. Genetic control of the innate immune response to Borrelia hermsii influences the course of relapsing fever in inbred strains of mice. Infection and Immunity 2010; 78: 586-594.
  2. Iliopoulou B, Guerau-De-Arellano M, Huber B. HLA-DR alleles determine responsiveness to Borrelia burgdorferi antigens in a mouse model of self-perpetuating arthritis. Arthritis Rheum 2009; 12: 3831-3840.
  3. Cassiani-Ingoni R, Cabral E, Lunemann J, Garza Z, Magnus T, Gelderblom H, Munson P, Marques A, Martin R. Borrelia burgdorferi induces TLR1 and TLR2 in human microglia and peripheral blood monocytes but differentially regulates HLA-Class II expression. J Neuropathol Exp Neurol 2006; 65: 540-548.
  4. Seward R, Drouin E, Steere A, Costello C. Peptides presented by HLA-DR molecules in synovia of patients with rheumatoid arthritis or antibiotic-refractory Lyme arthritis. Mol Cell Proteomics 2011; 3: M110.00247. doi.1074/mcp.M110.002477.
  5. Kovalchuka L, Eglite J, Lucenki I, Zalite M, Viksna L, Krumina A. Associations of HLA DR and DQ molecules with Lyme borreliosis in Latvian patients. BMC Research Notes 2012; 5: 438.
  6. Cabral E, Gelderblom H, Hornung R, Munson P, Martin R, Marques A. Borrelia burgdorferi lipoprotein-mediated TLR2 stimulation causes the down-regulation of TLR5 in human monocytes. Journal of Infectious Diseases 2006; 6: 849-859.
  7. Strle K, Shin J, Glickstein L, Steere A. Association of a toll-like receptor 1 polymorphism with heightened Th1 inflammatory responses and antibiotic-refractory Lyme arthritis. Arthritis & Rheumatism 2012; 5: 1497-1507.
  8. Berende A, Oosting M, Kullberg B, Netea M, Joosten L. Activation of innate host defense mechanisms by Borrelia. Eur Cytokine Network 2012; 1: 7-18.
  9. Drouin E, Seward R, Strle K, McHugh G, Katchar K, Londono D, Yao C, Costello C, Steere A. A novel human autoantigen, endothelial cell growth factor, is a target of T and B cell responses in patients with Lyme disease. Arthritis Rheum 2013; 1: 186-96.

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