I find that if I mix cholestyramine with applesauce the side affects of bloating and constipation are reduced. My plan is to take applesauce and my dose of cholestyramine in separate containers with me when I am away from the home. I would mix the two ingredients just before using the medication. What would happen if I premixed the cholestyramine with applesauce at home and brought them in a single container and not separate containers?
I have never collected data on this interesting question. Technically, the longer cholestyramine stays in contact with applesauce the likely there will be binding either to humic acid or fulvic acid. There may be other anions that will slowly bind cholestyramine if you premix the ingredients. My suggestion would be to simply use Welchol when you travel and avoid the hassle of worrying about cholestyramine mixtures.