Dr. Shoemaker announces "Actino Central" on Surviving Mold
Below are the current articles featured, but new articles will always be posted to Actino Central
Molecular metabolism and inflammation:
This paper from 2020, marks the initiation of understanding the role of hypometabolism and abnormalities of pyruvate that lead to presence in cases of metabolic acidosis, pulmonary hypertension, Treg cell deficiency, insulin resistance and neuronal injury. All of the papers to read and understand, this is the most difficult but it is also the most important.
Medical Research Archives, vol 9 issue 3.
Newer Molecular Methods Bring New Insights in human and building risk assessments.
This was the first paper in the CIRS literature to note the role of Next Generation Sequencing in transcriptomics following exposure to Actinobacteria. It also reviews the literature showing failure to eradicate actinobacteria is incredibly common following standard fungal cleansing methods. This is the first of the true actinobacteria in CIRS papers and is a must read.
Medical Research Archives vol 9 issue 7.
Treatable metabolic and inflammatory abnormalities in Post COVID Syndrome.
This is the first paper to show the role of Post COVID syndrome as a precipitating event for abnormalities in transcriptomics for CIRS patients. This paper looks at 24 patients who are well in a given building, had COVID, recovered from COVID, developed worsening called Post COVID Syndrome. We show the development of accentuated transcription of genes involved with Actinobacteria exposure and endotoxin exposure. This lends insight into why certain people will not have illness symptoms despite exposure to water-damaged buildings.
Medical Research Archives vol 9 issue 11.
Exposure to Actinobacteria resident in water-damaged buildings and resultant immune injury in CIRS.
This paper extends research on actinos showing the role of accentuated production of receptors for TGF Beta1, called TGFBR1, TGFBR2, TGFBR3. These genes show that the initial injury of inflammation leads to an immune reactive syndrome that gives specific causation for Actinobacteria and endotoxins.
Medical Research Archives vol 10 issue 1. Screening for Biomarkers of Actinobacteria.
This is the seminal paper showing the role of mycolic acid moieties in cell membranes of Actinobacteria. These mycolic acid structures lead to development of extracellular vesicles which in turn creates systemic inflammatory illnesses from Actinobacteria that are resident deep in sebaceous glands and oil glands. If there is one paper that demonstrates the complexity of human illness from Actinobacteria, this is the one to read.