Actino Central

Actino Coffeehouse discussion via Zoom from December 9, 2023!  

Proficiency Partner Jenny Johnson presented Actino Cofeehouse December 9th.  Thank you to Dr. Shoemaker, Dr. Dorninger and Larry Schwartz for presenting at Actino Coffeehouse yesterday! Such wonderful and important information you each shared.  

Listen to the replay here!

Passcode: ActinoCoffeehouse2023!
 

Actino Jeopardy-

Download the documents below and play along

Questions Only   Questions and Answers

 

Actino Central Documents

Here are a collection of the most current articles relating to Actinos and CIRS.  Please click the title of any article to open the full paper.
Medical Research Archives/ European Society of Medicine -Published December 2023
TUBB1, TUBA4A and MAPK as Indicators of Die­Back Degenerative Central Nervous System Disease in Patients Sickened by Specific Exposure to the Interior Environment of Water- Damaged Buildings

Beginning with Possible Estuarine Associated Syndrome (PEAS) in 1998 and followed by numerous studies on similar types of exposures, patients with illness associated with biotoxin exposure routinely have had symptom rosters dominated by executive cognitive dysfunction, including recent memory deficits, difficulty in concentration, difficulty with word finding, decreased assimilation of new knowledge, confusion and disorientation, tremors, headaches, vertigo, and unusual pains. In addition, tremors, headaches, vertigo, unusual pains and metallic taste. Toxins involved variously have included those found in toxin-forming dinoflagellates, including Pfiesteria and ciguatera; cyanobacteria, including Microcystis, Cylindrospermopsis and Lyngbya wollei; post Lyme syndrome and Babesia; as well as organisms found in damp buildings, including Aspergillus versicolor and A. penicillioides, Stachybotrys chartarum, Chaetomium globosum, Wallemia sebi, Actinobacteria species, especially Corynebacteria tuberculostearicum and Propionibacterium acnes; as well as bacterial endotoxins and beta-glucans. These illnesses have been called chronic inflammatory response syndromes (CIRS).
 

Medical Research Archives/ European Society of Medicine -Published March 2023
Transcriptomics and Brain Volumetrics Define the Causes of Cognitive Impairment in Patients with CIRS and Support the use of VIP in Treatment

Problems with executive cognitive function, including recent memory, concentration, word finding, confusion, decreased assimilation, and disorientation, can have a variety of sources of disease, including inflammation, metabolic disturbances, and degenerative processes that are typically found in diseases where chronic fatigue is present. The problems presented by multiple coexisting cognitive symptoms are finding: 1) a single diagnostic test that has a history of use by clinicians working with brain-injured patients, such as NeuroQuant (NQ); 2) that is affordable, accurate, and reliable to use as a measure of benefits, or lack of same; and 3) screening, causation, and sequential features of therapy. Furthermore, the complexity of brain injury shows us the limitations of human versus machine-based testing, with advances in transcriptomics leading the way in a new world of diagnostics and therapies that follow gene activation studies.

The objective of this report was to retrospectively look at results of the transcriptomic testing of white blood cells, combined with a brain volumetric imaging study, in an observational study to provide a basis to identify the specific causation of brain injury caused by exposure to the interior environment of water-damaged buildings (WDB).

Molecular metabolism and inflammation:

This paper from 2020, marks the initiation of understanding the role of hypometabolism and abnormalities of pyruvate that lead to presence in cases of metabolic acidosis, pulmonary hypertension, Treg cell deficiency, insulin resistance and neuronal injury. All of the papers to read and understand, this is the most difficult but it is also the most important.

Medical Research Archives, vol 9 issue 3.

Newer Molecular Methods Bring New Insights in human and building risk assessments.

This was the first paper in the CIRS literature to note the role of Next Generation Sequencing in transcriptomics following exposure to Actinobacteria. It also reviews the literature showing failure to eradicate actinobacteria is incredibly common following standard fungal cleansing methods. This is the first of the true actinobacteria in CIRS papers and is a must read.

 

Medical Research Archives vol 9 issue 7.

Treatable metabolic and inflammatory abnormalities in Post COVID Syndrome.

This is the first paper to show the role of Post COVID syndrome as a precipitating event for abnormalities in transcriptomics for CIRS patients. This paper looks at 24 patients who are well in a given building, had COVID, recovered from COVID, developed worsening called Post COVID Syndrome. We show the development of accentuated transcription of genes involved with Actinobacteria exposure and endotoxin exposure. This lends insight into why certain people will not have illness symptoms despite exposure to water-damaged buildings.

 

Medical Research Archives vol 9 issue 11.

Exposure to Actinobacteria resident in water-damaged buildings and resultant immune injury in CIRS.

This paper extends research on actinos showing the role of accentuated production of receptors for TGF Beta1, called TGFBR1, TGFBR2, TGFBR3. These genes show that the initial injury of inflammation leads to an immune reactive syndrome that gives specific causation for Actinobacteria and endotoxins.

 

Medical Research Archives vol 10 issue 1. Screening for Biomarkers of Actinobacteria.

This is the seminal paper showing the role of mycolic acid moieties in cell membranes of Actinobacteria. These mycolic acid structures lead to development of extracellular vesicles which in turn creates systemic inflammatory illnesses from Actinobacteria that are resident deep in sebaceous glands and oil glands. If there is one paper that demonstrates the complexity of human illness from Actinobacteria, this is the one to read.

Urinary Mycotoxins: A Review of Contaminated Buildings and Food in Search of a Biomarker Separating Sick Patients from Controls- October 2019

This review looks at the extensive published materials, including a definition of mycotoxins; a case definition for illness acquired following exposure to WDB from 2008 US GAO, multiple biomarkers, proteomics, transcriptomics, volumetric CNS imaging studies and more supporting the diagnosis of an active chronic inflammatory response syndrome (CIRS), acquired following exposure to the interior environment of WDB as a validated diagnosis that leads to use of published therapies with documented efficacy.

 

Medical Research Archives December 31, 2023 TUBB1, TUB4A, and MAPK as Indicators of Die-Back Degenerative Central Nervous System Disease in Patients Sickened by Specific Exposure to the Interior Environment of Water-Damaged Buildings

ABSTRACT: Hypoxia-inducible factor 1A (HIF 1A) is an oxygen-sensing nuclear transcription factor that regulates oxygen homeostasis in many illnesses ranging from, but not limited to, cancer, heart failure, premature infants to viral infections. We report here the measurement of HIF 1A using transcriptomics as a biomarker in Chronic Inflammatory Response Syndrome (CIRS), a systemic inflammatory and metabolic illness characterized by a multisystem, multi-symptom illness acquired following exposure to the interior environment of water-damaged buildings (WDB).

 

Medical Research Archives March 31, 2024 -Exposure to the Interior Environment of Water-Damaged Buildings Can Activate HIF 1A, Induce Proliferative Physiology and Impair Mitochondrial Metabolism

Hypoxia-inducible factor 1A (HIF 1A) is an oxygen-sensing nuclear transcription factor that regulates oxygen homeostasis in many illnesses ranging from, but not limited to, cancer, heart failure, premature infants to viral infections. We report here the measurement of HIF 1A using transcriptomics as a biomarker in Chronic Inflammatory Response Syndrome (CIRS), a systemic inflammatory and metabolic illness characterized by a multisystem, multi-symptom illness acquired following exposure to the interior environment of water-damaged buildings (WDB).