Determining Genetic Predisposition to Chronic Inflammatory Response Syndrome

Posted on March 1st, 2017

Surviving Mold offers mold test kits, mold remediation resources, and treatment by Dr. Shoemaker certified physicians.

Chronic Inflammatory Response Syndrome can affect an individual’s entire body and present with a variety of symptoms that make it tougher for doctors to correctly diagnose the condition.

Those who are interested in finding ways to more easily determine an individual’s risk of developing CIRS or who have the condition may want to learn about a patient’s genetic predisposition. About a quarter of the population has a genetic predisposition to the condition.

Related: Genomics to Improve Diagnosis, Treatment of CIRS

The role of proteins in CIRS

Certain HLA types can point to a susceptibility to the condition. The HLA-DR/DQ test looks at a specific gene that encodes a MHC Class 2 protein; the gene is found on Chromosome 6. It is this specific class of proteins that has a large role in determining whether a person may develop CIRS or not. These proteins tell the body about biotoxins and other things that affect the immune system.

When this protein presents an incomplete picture of the biotoxin to the immune system, it launches the body into a fight against the invader, which creates inflammation and pain for those who are affected by exposure to a water damaged building.

After learning about the test from Dr. Shoemaker, Dr. Dave Ou has reported that he has, as of November 2012, tested 227 individuals for this class of proteins, and found that 222 of those people have one of at least 10 different proteins that fail to allow the immune system to learn about the biotoxin in order to fight it, which can lead to CIRS.

Testing for CIRS susceptibility

There are a couple of lab tests that can tell you more about an individual’s potential for developing CIRS. These are LA Class II DRB1, DQ, and the HLA DRB 3*4*5 exam.

There are a few lab tests that can illuminate the degree of immune system activation as well. Some of these include Complement C3a and C4a, Melanocyte Stimulating Hormone, and Vascular Endothelial Growth Factor (VEGF), among others.

Visual contrast sensitivity (VCS) testing is another way to determine if an individual is affected by neurotoxins: this testing looks at the optic nerve but is just one tool that should be used in diagnosing CIRS.

Related: Genomics to Improve Diagnosis, Treatment of CIRS

Treatment for those who are susceptible

The results of these specific tests can help you to develop effective treatments for individuals who are at risk of developing CIRS.

Treatment should include removal of mold exposure, but for some patients, there may be as many as a dozen steps to treat chronic inflammatory response syndrome. Some steps in the protocol are designed to give more information. Environmental Relative Moldiness Index rating, or examination of a building for mold issues,  should also occur early in the process and patients should be removed from potentially harmful areas.

Other steps include correction of toxin levels in the body, and levels of other substances within the body, like VEGF, C3a, and C4a. From there, immune system support, nutritional support, and ingestion of a bile acid sequestrant to prevent these toxins from being reabsorbed by the body may be part of the treatment plan.

If you’re concerned that your patient’s symptoms are something other than the frequently diagnosed (and not always understood) conditions like fibromyalgia and stress, we encourage you to take the time to learn about Dr. Shoemaker’s protocol and what it takes to become certified.



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